Preheat your oven to 400°F (200°C) and prepare a baking sheet with parchment paper or foil.
In a bowl, mix together the cream cheese, shredded cheddar cheese, garlic powder, onion powder, and smoked paprika until smooth and well combined.
Cut the smoked sausage into evenly sized bite pieces to ensure they cook uniformly.
Take each jalapeño slice and spread a small layer of the cheese mixture over the top.
Set a sausage piece on each jalapeño slice, pressing lightly so it stays in place.
Wrap each assembled bite with a strip of thinly sliced beef, making sure it covers the sausage and jalapeño securely.
Fasten each piece with a toothpick to keep everything intact while baking.
Place the bites onto the prepared baking sheet, spacing them slightly apart.
Bake for 18–22 minutes, or until the beef edges are slightly crisp and the cheese is melted and bubbling.
Remove from the oven and allow them to rest briefly before serving so the filling can set.