Preheat oven to 350°F (175°C). 
In a large bowl, combine ground beef, ground pork (or turkey), egg, breadcrumbs, ketchup, Worcestershire sauce, garlic powder, onion powder, salt, and black pepper. Mix well. 
Press mixture evenly into the bottom of a 9×13-inch baking dish. 
Bake in preheated oven for 25 minutes. 
Meanwhile, cook macaroni according to package instructions. Drain and set aside. 
In a saucepan, melt butter over medium heat. Stir in flour until smooth. 
Gradually whisk in milk and chicken broth. Cook and stir until thickened, about 5 minutes. 
Stir in shredded cheddar cheese until melted. 
Remove meatloaf from oven and pour cheese sauce over the top. Sprinkle with shredded mozzarella cheese. 
Return to oven and bake for an additional 10 minutes, or until cheese is melted and bubbly. 
Serve hot and enjoy! 
Notes :
 Substitute pork with ground turkey for a healthier option. 
 For a vegetarian version, substitute ground beef and pork with plant-based alternatives.